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University of North Carolina at Chapel Hill, Joint Department of Biomedical Engineering 
Fall 2018, Fall 2019, Fall 2020, Fall 2021; BMME 890-014 / BMME 490-003
Fall 2022; BMME 523-001/BMME 890-015

Biomolecular Engineering (3 credit)

This course will target upper level undergraduate and entry level graduate students.  The course will introduce the concept of the use and creation of Biomolecules for Biomedical applications. The main purpose of the course is to foster the development of a mission oriented research plan to create engineered biomolecules for biomedical applications.  Students will search, prepare, evaluate, design, and simulate biomolecules. The format will include overview lectures on the basic chemical and structural properties of biomolecules, introductory lectures on exploiting varieties of biomolecules, tutorial lectures to learn the practical method to engineer biomolecules, and student presentations about their own research plans. The goals of the course are to 1) discuss varieties of biomolecules, 2) understand the strategies of how one can design and prepare biomolecules of their interest, and 3) illustrate how novel and original biomolecules can contribute to the creation of innovative biomedical technologies. 

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University of North Carolina at Chapel Hill, Joint Department of Biomedical Engineering 
Biosensors and Bioelectronics:  BMME 890-005 (3 credit) 
Spring 2019  
University of North Carolina at Chapel Hill, Joint Department of Biomedical Engineering 
Spring 2020, Spring 2021, Spring 2022; BMME 890-005/ BMME 490-003 
Spring 2023; BMME 524-001/BMME 890-005

Biomolecular Sensing Technologies:  (3 credit) 

This course will target graduate students and upper level (senior and junior) under graduate students.  The course will introduce the science and technology of Biomolecular Sensing Technologies, the essence of biosensors, and biochemical and immunological in vitro/in vivo diagnositc devices. In this class, biomolecules (enzymes and antibodies, aptamers), bioelectronics and biochemical principles employed in the biosensor development are specifically focused. The main purpose of the course is to foster the idea of a mission oriented plan to design and develop biosensors and diagnostic devices for biomedical applications, especially in the field of clinical diagnosis and self-care, by identifying particular problems in biomedical fields which will be solved by biosensors. 

The format is composed of a formal lecture including a review and discussion of research paper, case studies of biosensor and diagnostic devices using commercially available biosensors, and student project presentation. 

The formal lecture will be broken into four parts; 1) overview lectures on the principles of biosensors and diagnostic devices, biomolecules for biosensor, 2) the review of recent biosensor development, 3) the case studies of biosensors, and 4) final presentations by students. 

The case studies will be organized as the live demonstration of biosensors, including the preparation of biosensors and operations of biosensors, which are carried out at the instructor’s laboratory. The case studies aim to investigate and understand the composition, components, structure, principle, and utility (and recipe!) of the practical biosensor utilized in the medical field/self-care, and to understand the strategic design of biosensors. The market-driven technological development of the biosensor in the diabetes care business will be also introduced.  Finally, students will present their research project on the development of biosensors for particular biomedical purposes, which is the last part of the course.

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